Curable Taps Regeneron, Mayo Clinic for Liver Disease Sequencing Scheme

Thursday, November 17, 2016

Source: FierceBiotech

Research accelerator Curable is launching an international project to sequence at least 5,000 genomes of patients with an autoimmune disease that can result in liver failure. To aid that effort, it has recruited the Regeneron Genetics Center and Mayo Clinic.

Primary sclerosing cholangitis, or PSC, a condition that causes inflammation and scarring of the bile ducts, affects about 50,000 people in the U.S. This can lead to cirrhosis, or the replacement of liver tissue with scar tissue, and eventually liver failure. The causes of PSC are unclear, and short of liver transplant, current treatments are limited to managing symptoms.

“Through sequencing and genetic analysis, we will be able to learn more about the genetic basis of PSC and hope to uncover actionable findings for drug discovery and genomic medicine,” said Dr. Aris Baras, vice president and co-head of the Regeneron Genetics Center, in a statement.

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